Targeting Lynch Victims

Enhanced gene targeting to evaluate Lynch syndrome alterations.

The identification of gene alterations that predispose individuals to disease has resulted in an explosion in genetic diagnostics. Because diseases like cancer susceptibility may result in debilitating surgery that has physical, emotional, and realized costs, it is important to get the diagnosis right. The obvious solution is to combine simple DNA genotype analysis with evocative phenotype anal...

G Lynch

meant by "more effective." This unqualified assertion is likely to confuse the many people who already use or recommend All-Bran as an "effective" means of avoiding constipation whatever its soluble:insoluble fibre ratio or influence on plasma lipids, mineral absorption, faecal bulking, bowel transit time, etc. Furthermore, it is difficult to see why "wholemeal bread and crispbreads" are the on...

Sean Lynch ,

Victims of crime as victims of disaster.

The gross disparity between the routine attention paid to criminals and that paid to their victims led to the proposition that victims of major crime be treated as victims of disaster. The fresh appraisal might provide the impetus for appropriate services for them as a matter of social policy.

Diagnosing Lynch syndrome

R isk stratification is essential for designing efficacious and cost effective colon cancer screening programmes. One of the most important risk factors for colorectal cancers (CRC) is an inherited predisposition, implicated in 20% of all cases. The spectrum of genetic susceptibility ranges from the low penetrance mutations that modestly increase the colon cancer risk (for example, I 1307K) to ...